- For the upcoming episode of Superman & Lois, see "Broken Trust" .
After years of facing megalomaniacal supervillains, monsters wreaking havoc on Metropolis, and alien invaders intent on wiping out the human race, the world's most famous superhero, The Man of Steel aka Clark Kent and comic books' most famous journalist, Lois Lane, come face to face with one of their greatest challenges ever - dealing with all the stress, pressures and complexities that come with being working parents in today's society. Complicating the already daunting job of raising two boys, Clark and Lois must also concern themselves with whether or not their sons Jonathan and Jordan could inherit their father's Kryptonian superpowers as they grow older. Returning to Smallville to handle some Kent family business, Clark and Lois are reacquainted with Lana Lang, a local loan officer who also happens to be Clark's first love, and her Fire Chief husband Kyle Cushing. The adults aren't the only ones rediscovering old friendships in Smallville as the Kent sons are reacquainted with Lana and Kyle's rebellious daughter, Sarah. Of course, there's never a dull moment in the life of a superhero, especially with Lois' father, General Samuel Lane looking for Superman to vanquish a villain or save the day at a moment's notice. Meanwhile, Superman and Lois' return to idyllic Smallville is set to be upended when a mysterious stranger enters their lives.
- Tyler Hoechlin as Superman (Clark Kentl)
- Elizabeth Tulloch as Lois Lane
- Jordan Elsass as Jonathan Kent
- Alex Garfin as Jordan Kent
- Dylan Walsh as Sam Lane
- Emmanuelle Chriqui as Lana Lang Cushing
- Erik Valdez as Kyle Cushing
- Inde Navarrette as Sarah Cushing
- Wolé Parks as Captain Luthor
- Dylan Walsh as Morgan Edge
- Joselyn Picard as Sophie Cushing
- Fritzy-Klevans Destine as Sean Smith
- Dee Jay Jackson as Cobb Branden
- Sofia Hasmik as Chrissy Beppo
- Stacey Farber as Leslie Larr
- TBA as Ron Troupe
- The title is an indirect reference to the television series, Lois & Clark: The New Adventures of Superman.
- There was a planned crossover episode with the second season of Batwoman that was cancelled due to the COVID-19 Pandemic.
- The first season was originally meant to have 13 episodes but this was later changed to 15.